The new franchise has replaced MG Rover and has a refurbished showroom in line with Nissan standards.
A service reception is included in the showroom with a dedicated workshop now situated to the rear of the premises.
David Tuomey, Windsors group managing director said: "We are delighted to represent Nissan in the Wirral, particularly at this exciting time for the manufacturer with the launch of the Qashqai and other new exciting products over the next few years."
The new Nissan franchise gives Windsors five major franchises, three at Wallasey – Nissan, Citroen and Mazda, and two at Heswall – Peugeot and Fiat.
Windsors established in 1921, operate sales service and parts for each of the franchises held and also operate a bodyshop in Wallasey. They employ a workforce of 90 across the two sites.