Offenders who have failed to pay court fines could find themselves wheel-clamped or arrested - and have money taken from their bank accounts.
The new campaign is also being advertised in men's magazines in a bid to target some of the worst offenders.
Currently, nearly £390 million of financial payments are outstanding in England and Wales.
A new deal has been reached to link up mobile Automatic Number Plate Recognition (ANPR) equipment with the magistrates' courts database of fine defaulters.
People caught by the new campaign, Operation Payback 2, could have unpaid fines deducted from their wages or some benefits.
Their cars could be clamped or they could even face jail.
The first Operation Payback netted £750,000 earlier this year. This new campaign will focus on London, Manchester, the West Midlands, West Yorkshire and Merseyside.