The show, which is running for the fourth time, is set up as a retail promotion to get business workers out of their offices and looking at the cars on display.
More than 45 exhibitors will display in excess of 250 cars in an area covering a total of 97 acres.
Chris Coleman-Brown, Motorexpo press officer, said: “The average salary of workers in Canary Wharf is £100,000, with some of the regular attendees earning bonuses between £2m and £10m.
They are time poor and cash rich, which is why premium badges like coming here.”
Last year’s Motorexpo attracted 325,000 visitors. This year Coleman-Brown anticipates up to 370,000, with the increase mostly made up of the new workers colonising Canary Wharf.
The Marcos TSO RT is due to make its world debut at the show while 21 marques including Bentley and Aston Martin will give vehicles UK show debuts.