The Society of Motor Manufacturers and Traders (SMMT) expects around 330,000 new cars to be registered during September, with motorists spending in the region of £4.95 billion on the latest new vehicles.
September is the second biggest month for dealers across the UK and accounts for almost a fifth of the year's trade, with the other plate-change month of March traditionally the busiest.
More than 300 fuel-efficient, technology-packed models are currently on the market, representing one of the biggest ever choices for UK motorists.
Paul Everitt, SMMT chief executive, said: "September is a significant month for the UK motor industry and the wider economy.
"A strong month for new vehicle registrations will help put both on the right track.
"Franchised dealers have a fantastic range of exciting new models on offer, each with enhanced levels of fuel efficiency, safety, comfort and affordable finance.
"These advantages make it a great time to buy a new car and motorists should visit their local dealer to secure a new 62-plate in September."